| Pick | Team | Player | Postition | College |
| 1 | Indianapolis Colts | Andrew Luck | QB | Stanford |
| 2 | Washington Redskins | Robert Griffin III | QB | Baylor |
| 3 | Cleveland Browns | Trent Richardson | RB | Alabama |
| 4 | Minnesota Vikings | Matt Kalil | OT | USC |
| 5 | Jacksonville Jaguars | Justin Blackmon | WR | Oklahoma State |
| 6 | Dallas Cowboys | Morris Claiborne | CB | LSU |
| 7 | Tampa Bay Buccaneers | Mark Barron | S | Alabama |
| 8 | Miami Dolphins | Ryan Tannehill | QB | Texas A&M |
| 9 | Carolina Panthers | Luke Kuechly | ILB | Boston College |
| 10 | Buffalo Bills | Stephon Gilmore | CB | South Carolina |
| 11 | Kansas City Chiefs | Dontari Poe | DT | Memphis |
| 12 | Philadelphia Eagles | Fletcher Cox | DT | Mississippi State |
| 13 | Arizona Cardinals | Michael Floyd | WR | Notre Dame |
| 14 | St. Louis Rams | Michael Brockers | DT | LSU |
| 15 | Seattle Seahawks | Bruce Irvin | OLB | West Virginia |
| 16 | New York Jets | Quinton Coples | DE | North Carolina |
| 17 | Cincinnati Bengals | Dre Kirkpatrick | CB | Alabama |
| 18 | San Diego Chargers | Melvin Ingram | DE | South Carolina |
| 19 | Chicago Bears | Shea McClellin | OLB | Boise State |
| 20 | Tennessee Titans | Kendall Wright | WR | Baylor |
| 21 | New England Patriots | Chandler Jones | DE | Syracuse |
| 22 | Cleveland Browns | Brandon Weeden | QB | Oklahoma State |
| 23 | Detroit Lions | Riley Reiff | OT | Iowa |
| 24 | Pittsburgh Steelers | David DeCastro | G | Stanford |
| 25 | New England Patriots | Dont’a Hightower | ILB | Alabama |
| 26 | Houston Texans | Whitney Mercilus | DE/OLB | Illinois |
| 27 | Cincinnati Bengals | Kevin Zeitler | G | Wisconsin |
| 28 | Green Bay Packers | Nick Perry | DE | USC |
| 29 | Minnesota Vikings | Harrison Smith | S | Notre Dame |
| 30 | San Francisco 49ers | A.J. Jenkins | WR | Illinois |
| 31 | Tampa Bay Buccaneers | Doug Martin | RB | Boise State |
| 32 | New York Giants | David Wilson | RB | Virginia Tech |
