Which of the favorites will fall in Week 10 of the 2015 NFL season?

Four games in particular could contain the necessary ingredients for a tasty upset. The point spreads are based on Sports Book Review’s consensus odds as of Friday afternoon.

Cleveland (+5 1/2) at Pittsburgh

The Steelers (5-4) have won without Ben Roethlisberger this season. They’ve won without Le’Veon Bell this season. But they haven’t won without both Roethlisberger and Bell. The latter is out for the season and Roethlisberger is listed as questionable for Sunday’s game, according to the Pittsburgh Post-Gazette. The Steelers are prepared for Landry Jones to make his second start. Jones has led the Steelers to victories in relief of both Roethlisberger and Mike Vick this season, but he lost his only start at Kansas City in Week 7. The Browns (2-7) haven’t won at Pittsburgh since 2003, but they’ve had 10 days of rest and came back from a 27-3 deficit at Pittsburgh last year before losing 30-27.

Jacksonville (+5 1/2) at Baltimore

This just isn’t the Ravens’ year. They’re 2-6 and they’ll be without Steve Smith Sr. for the rest of the season. That leaves Chris Givens (seven receptions, one with the Rams) and Kamar Aiken (25 receptions) as Joe Flacco’s top wide receivers. The Jaguars (2-6), meanwhile, have shown signs of a team on the rise. They came back from a 27-3 deficit to beat the Bills 34-31 at London in Week 7, and the stock of that victory rose Thursday night. In a 28-23 loss to the Jets last week, Allen Robinson caught six passes for 121 yards against Darrelle Revis. Imagine what he can do against the Ravens’ 29th-ranked pass defense.

Arizona (+3) at Seattle

The Seahawks (4-4) really haven’t beaten anyone this year. Their wins have come against the Bears, Lions, 49ers and Matt Cassel-led Cowboys. OK, so the Cardinals (6-2) really don’t have a statement win, either. They’ve beaten the Saints, Bears, Lions, 49ers, Ravens and Browns. However, Bruce Arians knows what it takes to win at Seattle. The Cardinals are one of just three visiting teams to win there since 2012. Arizona has the edge in the quarterback department. Both Carson Palmer and Russell Wilson have thrown six interceptions this season. But Palmer has 20 touchdown passes and Wilson has just nine.

Carolina at Tennessee (+4 1/2)

Unlike the Patriots, the Panthers aren’t used to being surrounded by whispers of a perfect season. The weight of perfection could start to take its toll. The Panthers won a showdown of elite NFC teams last week, beating the Packers 37-29. They’re ripe for a letdown this week. The Titans, meanwhile, have a little momentum going after rallying from a 21-10 deficit to beat the Saints 34-28 in overtime at New Orleans last week under new coach Mike Mularkey. The Panthers haven’t been finishing strong lately. They led 37-14 in the fourth quarter before holding off the Packers last week and blew a 17-point, fourth-quarter lead before beating the Colts at home in OT in Week 8.